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Tirzepetide
Tirzepatide - Image 2

Tirzepatide

4.9 (312 reviews)

⭐ See Our ReviewsPilot Profile
GIP/GLP-1 Dual Agonist Incretin Mimetic Metabolic Research
Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist under investigation for metabolic research applications.
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4,813

MOLECULAR WEIGHT
Daltons

39

AMINO ACIDS
Peptide sequence

800+

STUDIES
Published research

99%+

PURITY
HPLC verified

Product Details

  • Molecular Formula: C225H348N48O68
  • Molecular Weight: 4813.45 g/mol
  • Appearance: White lyophilized powder
  • Storage: Store at -20°C
  • Purity: ≥99% (HPLC)
  • Research Use Only
  • Clinical Research Results

Key findings from published peer-reviewed research studies.

22.5%

Avg Weight Reduction

2.58%

HbA1c Reduction

72wk

SURMOUNT-1 Duration

Dual

GIP/GLP-1 Agonist

Glycemic Control (SURPASS Trials)

Superior HbA1c reduction compared to existing treatments

Phase 3 SURPASS trial data demonstrated dose-dependent HbA1c reductions of up to 2.58% from baseline, surpassing the efficacy of comparator agents.

Body Weight Reduction

Significant weight loss of up to 22.5% of body weight in clinical trials

SURMOUNT-1 trial showed participants receiving the highest dose achieved an average weight reduction of 22.5% over 72 weeks, representing a landmark finding in metabolic research.

Cardiovascular Markers

Significant weight loss of up to 22.5% of body weight in clinical trials

SURMOUNT-1 trial showed participants receiving the highest dose achieved an average weight reduction of 22.5% over 72 weeks, representing a landmark finding in metabolic research.

Cardiovascular Markers

Improvements in cardiovascular risk factors including lipid profiles

Data showed reductions in total cholesterol, triglycerides, and LDL-C, alongside improvements in blood pressure and inflammatory biomarkers.

Dual Receptor Mechanism

First-in-class dual GIP/GLP-1 receptor agonism provides enhanced efficacy

The dual incretin mechanism amplifies insulin secretion, suppresses glucagon, slows gastric emptying, and influences central appetite regulation pathways.

  • Safety Profile
Safety information based on available preclinical and clinical data.

Low

Hypoglycemia Risk

Mild

GI Side Effects

Safe

Pancreatic Profile

Gastrointestinal Effects

Most commonly reported: nausea, diarrhea, and decreased appetite. These effects were generally mild-to-moderate and transient, diminishing with continued use.

Pancreatic Safety

No increased risk of pancreatitis observed across clinical trial programs. Lipase/amylase elevations were monitored and remained within acceptable ranges.

Thyroid Considerations

GLP-1 receptor agonists carry a class warning regarding thyroid C-cell tumors observed in rodent studies. Clinical relevance in humans remains under investigation.

Hypoglycemia Risk

Low risk of hypoglycemia when used alone. Risk increases when combined with insulin or sulfonylureas in research protocols.

Injection Site Reactions

Mild injection site reactions (redness, itching) reported in a small percentage of study participants, typically resolving without intervention.

Disclaimer: This product is intended for research use only. Not for human consumption, therapeutic use, or diagnostic purposes.

  • Compound Information
Detailed chemical and physical properties.
MW

4,813 Da

Amino Acids

39

Purity

≥99%

Endotoxin

<0.1 EU/mg

Chemical Name Tirzepatide
CAS Number 2023788-19-2
Molecular Formula C₂₂₅H₃₄₈N₄₈O₆₈
Molecular Weight 4,813.45 g/mol
Peptide Length 39 amino acids
Mechanism Dual GIP/GLP-1 receptor agonist
Appearance White to off-white lyophilized powder
Solubility Soluble in sterile water, bacteriostatic water
Purity ≥99% (HPLC)
Endotoxin Level <0.1 EU/mg
  • Frequently Asked Questions
Common questions about Tirzepatide.

What is Tirzepatide?

Tirzepatide is a first-in-class dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. It was developed for metabolic research and has shown unprecedented efficacy in clinical trials.

How does Tirzepatide differ from GLP-1-only agonists?

Unlike GLP-1-only agonists (e.g., semaglutide), tirzepatide activates both GIP and GLP-1 receptors. This dual mechanism provides additive effects on insulin secretion, glucose control, and weight management in research models.

What are the SURPASS and SURMOUNT trials?

SURPASS is a series of Phase 3 clinical trials evaluating tirzepatide for type 2 diabetes. SURMOUNT trials investigate its use in obesity research. Both programs have demonstrated best-in-class efficacy.

How should this product be stored?

Store lyophilized tirzepatide at -20°C for long-term storage. Reconstituted solution should be stored at 2-8°C and used within 14 days.

What quality testing is performed?

Each batch undergoes HPLC purity analysis, mass spectrometry for identity, endotoxin testing, sterility testing, and residual solvent analysis to ensure pharmaceutical-grade quality.

  • Sources & References

Peer-reviewed publications and reference materials.

Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes (SURPASS-2)

Frías JP, Davies MJ, et al.

New England Journal of Medicine (2021)

DOI: 10.1056/NEJMoa2107519

Tirzepatide once weekly for the treatment of obesity (SURMOUNT-1)

Jastreboff AM, Aronne LJ, et al.

New England Journal of Medicine (2022)

DOI: 10.1056/NEJMoa2206038

Dual GIP/GLP-1 receptor agonism: a review of tirzepatide

Willard FS, Douros JD, et al.

Journal of Clinical Investigation (2020)

DOI: 10.1172/JCI137398

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