MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a mitochondria-derived peptide that regulates metabolic homeostasis. It has been shown to activate AMPK and improve glucose metabolism in research models.
Required to reconstitute lyophilized peptides before use in research.
Key findings from published peer-reviewed research studies.
Disclaimer: This product is intended for research use only. Not for human consumption, therapeutic use, or diagnostic purposes.
| Chemical Name | MOTS-c (Mitochondrial ORF of the 12S rRNA Type-C) |
| Origin | Encoded within mitochondrial 12S rRNA gene |
| Molecular Formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular Weight | 2,174.64 g/mol |
| Peptide Length | 16 amino acids |
| Sequence | MRWQEMGYIFYPRKLR |
| Mechanism | AMPK activator via folate-methionine cycle modulation |
| Appearance | White lyophilized powder |
| Purity | ≥99% (HPLC) |
| Endotoxin Level | <0.1 EU/mg |
MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA gene. It was discovered in 2015 and is the first mitochondrial-derived peptide shown to regulate metabolic homeostasis systemically.
MOTS-c primarily acts by inhibiting the folate-methionine cycle, leading to AMPK activation. This triggers downstream metabolic effects including enhanced glucose uptake, fatty acid oxidation, and improved insulin sensitivity.
MOTS-c activates many of the same metabolic pathways as physical exercise, including AMPK signaling, mitochondrial biogenesis, and improved glucose homeostasis. It’s also released into circulation during exercise.
Store lyophilized MOTS-c at -20°C. Reconstitute with bacteriostatic water and store at 2-8°C. Use reconstituted solution within 14 days.
Peer-reviewed publications and reference materials.
Our products are strictly intended for laboratory research use only. Not for human or animal consumption. By purchasing, you confirm that you are a licensed researcher or purchasing for research purposes.
