Required to reconstitute lyophilized peptides before use in research.
MOLECULAR WEIGHT
Daltons
STUDIES
Published research
BIOAVAILABILITY
IV formulation
PURITY
HPLC verified
Key findings from published peer-reviewed research studies.
Enzymatic Reactions
Age-Related Decline
Sirtuin Enzymes
Published Studies
NAD+ is essential for mitochondrial function and ATP production
Research has established NAD+ as a critical cofactor in the electron transport chain and TCA cycle, directly influencing cellular energy output and metabolic efficiency.
NAD+ is the required substrate for all seven sirtuin enzymes
Sirtuins (SIRT1-7) are NAD+-dependent deacetylases involved in DNA repair, gene expression, and aging. NAD+ supplementation has been shown to enhance sirtuin activity in research models.
Supports PARP-mediated DNA damage repair mechanisms
NAD+ is consumed by PARP enzymes during DNA repair processes. Maintaining adequate NAD+ levels supports genomic stability and cellular resilience to oxidative stress.
NAD+ levels decrease by up to 50% between ages 40-60
Multiple studies have documented the age-related decline in NAD+ levels and its correlation with metabolic dysfunction, neurodegeneration, and other age-associated conditions.
Tolerated IV
Metabolic Profile
Reconstituted Use
NAD+ IV infusion has been well-tolerated in clinical settings. Common transient effects include flushing, nausea, and chest tightness during rapid infusion.
Research dosing ranges from 250mg to 1000mg IV. Slow infusion rates (2-4 hours) significantly reduce side effects.
NAD+ may interact with medications affecting NAD+ metabolism. No serious adverse interactions reported in published literature.
Lyophilized powder stable at -20°C for 24+ months. Reconstituted solution should be used promptly or stored at 2-8°C for up to 24 hours.
Research use only. Caution in subjects with active malignancy, as NAD+ could theoretically support cancer cell metabolism.
Disclaimer: This product is intended for research use only. Not for human consumption, therapeutic use, or diagnostic purposes.
663 Da
Coenzyme
≥99%
500+
| Chemical Name | Nicotinamide Adenine Dinucleotide |
| CAS Number | 53-84-9 |
| Molecular Formula | C₂₁H₂₇N₇O₁₄P₂ |
| Molecular Weight | 663.43 g/mol |
| Type | Dinucleotide coenzyme |
| Function | Electron carrier, sirtuin substrate, PARP cofactor |
| Appearance | White to off-white lyophilized powder |
| Solubility | Freely soluble in water |
| Purity | ≥99% (HPLC) |
| Endotoxin Level | <0.5 EU/mg |
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell. It exists in oxidized (NAD+) and reduced (NADH) forms and is essential for over 500 enzymatic reactions in the body.
NAD+ levels decline due to increased consumption by CD38 (an NADase that increases with inflammation), reduced biosynthesis, and increased PARP activity from accumulated DNA damage.
NAD+ is the active coenzyme itself, while NMN and NR are precursors that the body converts into NAD+. Direct NAD+ supplementation bypasses the biosynthetic steps required for precursors.
Store lyophilized NAD+ at -20°C protected from light and moisture. Once reconstituted, use within 24 hours. NAD+ is sensitive to heat and light degradation.
Peer-reviewed publications and reference materials.
Our products are strictly intended for laboratory research use only. Not for human or animal consumption. By purchasing, you confirm that you are a licensed researcher or purchasing for research purposes.