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NAD+

NAD+

(176 reviews)

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Cellular Energy Coenzyme Longevity
Nicotinamide Adenine Dinucleotide (NAD+) is a critical coenzyme found in every cell of the body. It plays a central role in cellular energy metabolism, DNA repair, and sirtuin activation, making it a key focus of longevity research.
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663

MOLECULAR WEIGHT

Daltons

3,000+

STUDIES

Published research

100%

BIOAVAILABILITY

IV formulation

99%+

PURITY

HPLC verified

  • Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
  • Molecular Weight: 663.43 g/mol
  • Appearance: White to off-white lyophilized powder
  • Storage: Store at -20°C, protect from light
  • Purity: ≥99% (HPLC)
  • Research Use Only
  • Clinical Research Results

Key findings from published peer-reviewed research studies.

500+

Enzymatic Reactions

50%

Age-Related Decline

7

Sirtuin Enzymes

3,000+

Published Studies

Cellular Energy Metabolism

NAD+ is essential for mitochondrial function and ATP production

Research has established NAD+ as a critical cofactor in the electron transport chain and TCA cycle, directly influencing cellular energy output and metabolic efficiency.

Sirtuin Activation

NAD+ is the required substrate for all seven sirtuin enzymes

Sirtuins (SIRT1-7) are NAD+-dependent deacetylases involved in DNA repair, gene expression, and aging. NAD+ supplementation has been shown to enhance sirtuin activity in research models.

DNA Repair Enhancement

Supports PARP-mediated DNA damage repair mechanisms

NAD+ is consumed by PARP enzymes during DNA repair processes. Maintaining adequate NAD+ levels supports genomic stability and cellular resilience to oxidative stress.

Age-Related Decline

NAD+ levels decrease by up to 50% between ages 40-60

Multiple studies have documented the age-related decline in NAD+ levels and its correlation with metabolic dysfunction, neurodegeneration, and other age-associated conditions.

  • Safety Profile
Safety information based on available preclinical and clinical data.

Well

Tolerated IV

Safe

Metabolic Profile

24h

Reconstituted Use

Tolerability

NAD+ IV infusion has been well-tolerated in clinical settings. Common transient effects include flushing, nausea, and chest tightness during rapid infusion.

Dosing Range

Research dosing ranges from 250mg to 1000mg IV. Slow infusion rates (2-4 hours) significantly reduce side effects.

Drug Interactions

NAD+ may interact with medications affecting NAD+ metabolism. No serious adverse interactions reported in published literature.

Storage

Lyophilized powder stable at -20°C for 24+ months. Reconstituted solution should be used promptly or stored at 2-8°C for up to 24 hours.

Contraindications

Research use only. Caution in subjects with active malignancy, as NAD+ could theoretically support cancer cell metabolism.

Disclaimer: This product is intended for research use only. Not for human consumption, therapeutic use, or diagnostic purposes.

  • Compound Information
Detailed chemical and physical properties.
MW

663 Da

Type

Coenzyme

Purity

≥99%

Reactions

500+

Chemical Name Nicotinamide Adenine Dinucleotide
CAS Number 53-84-9
Molecular Formula C₂₁H₂₇N₇O₁₄P₂
Molecular Weight 663.43 g/mol
Type Dinucleotide coenzyme
Function Electron carrier, sirtuin substrate, PARP cofactor
Appearance White to off-white lyophilized powder
Solubility Freely soluble in water
Purity ≥99% (HPLC)
Endotoxin Level <0.5 EU/mg
  • Frequently Asked Questions
Common questions about Tirzepatide.

What is NAD+?

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell. It exists in oxidized (NAD+) and reduced (NADH) forms and is essential for over 500 enzymatic reactions in the body.

Why do NAD+ levels decline with age?

NAD+ levels decline due to increased consumption by CD38 (an NADase that increases with inflammation), reduced biosynthesis, and increased PARP activity from accumulated DNA damage.

How is NAD+ different from NMN or NR?

NAD+ is the active coenzyme itself, while NMN and NR are precursors that the body converts into NAD+. Direct NAD+ supplementation bypasses the biosynthetic steps required for precursors.

How should NAD+ be stored?

Store lyophilized NAD+ at -20°C protected from light and moisture. Once reconstituted, use within 24 hours. NAD+ is sensitive to heat and light degradation.

  • Sources & References

Peer-reviewed publications and reference materials.

NAD+ metabolism and its roles in cellular processes during ageing

Covarrubias AJ, et al.

Nature Reviews Molecular Cell Biology (2021)

DOI: 10.1038/s41580-020-00313-x

NAD+ in aging, metabolism, and neurodegeneration

Verdin E.

Science (2015)

DOI: 10.1126/science.aac4854

The Science Behind NMN: A Stable, Reliable NAD+ Activator

Yoshino J, et al.

Cell Metabolism (2018)

DOI: 10.1016/j.cmet.2017.12.016

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