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TB-500

TB-500

(210 reviews)

⭐ See Our ReviewsPilot Profile
Angiogenesis Thymosin Beta-4 Tissue Repair
TB-500 is a synthetic peptide of the protein thymosin beta-4. It plays a vital role in building new blood vessels, new small muscle tissue fibers, cell migration, and blood cell reproduction.
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4,963

MOLECULAR WEIGHT

Daltons

43

AMINO ACIDS

Peptide sequence

1,200+

STUDIES

Published research

99%+

PURITY

HPLC verified

  • Molecular Formula: C212H350N56O78S
  • Molecular Weight: 4963.44 g/mol
  • Sequence: Ac-SDKP
  • Appearance: White lyophilized powder
  • Storage: Store at -20°C
  • Research Use Only
  • Clinical Research Results

Key findings from published peer-reviewed research studies.

1,200+

Published Studies

87%

Wound Closure Rate

43aa

Peptide Sequence

3x

Faster Recovery

Wound Healing Acceleration

Significantly accelerated wound closure in dermal injury models

Studies demonstrated TB-500 promoted cell migration, angiogenesis, and collagen deposition, resulting in faster tissue repair compared to control groups.

Cardiac Tissue Repair

Improved cardiac function after ischemic injury in preclinical models

Research showed upregulation of Akt signaling pathway and enhanced cardiomyocyte survival, leading to improved left ventricular function post-injury.

Anti-Inflammatory Properties

Reduced inflammatory markers in multiple tissue types

TB-500 demonstrated suppression of NF-κB activation and reduced production of pro-inflammatory cytokines including TNF-α and IL-6.

Neurological Recovery

Enhanced neural recovery and reduced neuroinflammation

Preclinical data suggests TB-500 supports oligodendrocyte differentiation and promotes remyelination in central nervous system injury models.

  • Safety Profile
Safety information based on available preclinical and clinical data.

No

Organ Toxicity

24+mo

Shelf Stability

Wide

Therapeutic Index

Acute Toxicity

No significant adverse effects observed at standard research dosages in preclinical studies.

Chronic Exposure

Extended administration studies showed no organ toxicity or significant changes in hematological parameters.

Drug Interactions

No known interactions reported in published literature. Consult research protocols for combination studies.

Storage Stability

Lyophilized powder stable for 24+ months at -20°C. Reconstituted solution stable for up to 30 days at 2-8°C.

Contraindications

Research use only. Not for human consumption. Should not be used in subjects with known hypersensitivity to any component.

Disclaimer: This product is intended for research use only. Not for human consumption, therapeutic use, or diagnostic purposes.

  • Compound Information
Detailed chemical and physical properties.
MW

4,963 Da

Amino Acids

43

Purity

≥99%

Endotoxin

<0.1 EU/mg

Chemical Name Thymosin Beta-4 Fragment (17-23)
CAS Number 77591-33-4
Molecular Formula C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight 4,963.44 g/mol
Sequence Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
Appearance White to off-white lyophilized powder
Solubility Soluble in sterile water, bacteriostatic water
Purity ≥99% (HPLC)
Counter Ion Acetate (TFA-free)
Endotoxin Level <0.1 EU/mg
  • Frequently Asked Questions
Common questions about Tirzepatide.

What is TB-500?

TB-500 is a synthetic version of the naturally occurring 43-amino acid peptide thymosin beta-4 (Tβ4). It is one of the most abundant intracellular proteins and plays a critical role in tissue protection, repair, and regeneration.

How should TB-500 be stored?

Store lyophilized TB-500 at -20°C for long-term storage. Once reconstituted, store at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles.

What is the recommended reconstitution method?

Reconstitute with bacteriostatic water by gently injecting the solvent into the vial along the side wall. Allow the peptide to dissolve naturally without shaking or vortexing.

Is TB-500 the same as Thymosin Beta-4?

TB-500 is a synthetic analog of the active region of thymosin beta-4. While structurally similar, TB-500 is specifically designed for research applications with optimized stability and purity.

What purity testing does this product undergo?

Every batch undergoes HPLC analysis for purity verification, mass spectrometry for identity confirmation, endotoxin testing (LAL), sterility testing, and amino acid analysis.

  • Sources & References

Peer-reviewed publications and reference materials.

Thymosin β4 promotes wound healing and tissue regeneration

Malinda KM, Sidhu GS, et al.

Journal of Investigative Dermatology (1999)

DOI: 10.1046/j.1523-1747.1999.00708.x

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration

Bock-Marquette I, Saxena A, et al.

Nature (2004)

DOI: 10.1038/nature02582

Role of thymosin β4 in tissue repair and fibrosis

Goldstein AL, Hannappel E, et al.

Annals of the New York Academy of Sciences (2012)

DOI: 10.1111/j.1749-6632.2012.06596.x

Thymosin Beta-4 and its degradation products in ischemic brain injury

Morris DC, Chopp M, et al.

Journal of Neuroscience Research (2014)

DOI: 10.1002/jnr.23508

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